The Potential of Sirtuin 1 (SIRT1) Gene as a Biomarker of Frailty Syndrome in the Elderly: A Systematic Review

Abstract

The global population of older adults is steadily increasing, with aging inevitably linked to frailty, a condition characterized by physical weakness and vulnerability. Frailty in the elderly is often a precursor to chronic diseases, as the body experiences cumulative changes that compromise health over time. To mitigate the onset of chronic diseases in aging individuals, early detection of frailty is critical. One potential biomarker for frailty is the SIRT1 gene, which has garnered attention for its role in regulating aging and preventing degenerative conditions. This article explores the relationship between the SIRT1 gene, aging, and frailty. The SIRT1 gene, known for its role in cellular regulation and protection, is believed to be crucial in the aging process. As people age, maintaining high levels of SIRT1 activity can help prevent the onset of frail conditions and, in turn, reduce the likelihood of chronic diseases such as cardiovascular disorders, diabetes, and neurodegenerative diseases. Studies have shown that increased SIRT1 activity promotes resilience against cellular stress and inflammation, both of which contribute to frailty. Current research suggests that SIRT1 not only plays a role in aging but is also directly linked to frailty syndrome, making it a promising biomarker for early detection. The ability to identify individuals at risk of frailty through SIRT1 levels could pave the way for preventive interventions, potentially enhancing the quality of life for older adults. In conclusion, the SIRT1 gene holds significant promise as a biomarker for frailty, offering insight into the complex relationship between aging and chronic disease prevention.